Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5178279 | 0.81 | MAP2K1 (0.61) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL5559992 | 0.80 | MAP2K1 (0.52) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL5554511 | 0.79 | MAP2K1 (0.53) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL5555084 | 0.79 | MAP2K1 (0.52) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL3455907 | 0.78 | MAP2K1 (0.51) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL5560204 | 0.78 | MAP2K1 (0.66) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL388574 | 0.78 | MAP2K1 (0.61) | MAP2K1MAP2K2 | |
| SCHEMBL388765 | 0.77 | MAP2K1 (0.53) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL5559526 | 0.76 | MAP2K1 (0.60) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL5560829 | 0.76 | MAP2K1 (0.52) | MAP2K1MAP2K2ABCB11NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682138-A4 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1682138-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005051301-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |