Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5561738 | 0.86 | MAP2K1 (0.42) | MAP2K1MAP2K2PIM1CAMK2BMAPK1 | |
| SCHEMBL5559777 | 0.86 | MAP2K1 (0.59) | MAP2K1MAP2K2PIM1CAMK2BMAPK1 | |
| SCHEMBL388357 | 0.82 | MAP2K1 (0.76) | MAP2K1MAP2K2 | |
| SCHEMBL5559526 | 0.78 | MAP2K1 (0.60) | MAP2K1MAP2K2 | |
| SCHEMBL388611 | 0.75 | MAP2K1 (0.50) | MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL5990873 | 0.75 | MAP2K1 (0.74) | MAP2K1MAP2K2PIM1CAMK2BMAPK1 | |
| SCHEMBL5560204 | 0.74 | MAP2K1 (0.66) | MAP2K1MAP2K2 | |
| SCHEMBL392927 | 0.74 | MAP2K1 (0.62) | MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL392936 | 0.73 | MAP2K1 (0.69) | MAP2K1MAP2K2 | |
| SCHEMBL5554749 | 0.73 | MAP2K1 (0.52) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007511614-A | — | — | 2007-05-10 | — | — | JP | claimed |
| EP-1682138-A4 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-1682138-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005051301-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | claimed |
| EP-2251327-B1 | HETEROCYCLIC INHIBITORS OF MEK | ARRAY BIOPHARMA INC (US) | 2014-02-12 | — | — | EP | disclosed |