Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 7/20 | 0.49 |
| ▸ | SRC | P12931 | 5/20 | 0.49 |
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | AXL | P30530 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | FLT4 | P35916 | 3/20 | 0.49 |
| ▸ | KIT | P10721 | 3/20 | 0.49 |
| ▸ | MERTK | Q12866 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | GAK | O14976 | 2/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.49 |
| ▸ | STK10 | O94804 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | LYN | P07948 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5567176 | 0.89 | KDM1A (0.55) | KDM1AEGFRSRCKDRAXL | |
| SCHEMBL5566463 | 0.88 | AURKA (0.58) | KDM1AEGFRSRCKDRAXL | |
| SCHEMBL5566275 | 0.87 | KDM1A (0.57) | KDM1AEGFRSRCKDRAXL | |
| SCHEMBL5567304 | 0.87 | KDM1A (0.57) | KDM1AEGFRSRCKDRAXL | |
| SCHEMBL5560438 | 0.86 | KDM1A (0.53) | KDM1AEGFRSRCKDRAXL | |
| SCHEMBL5566886 | 0.86 | KDM1A (0.53) | KDM1AEGFRSRCKDRAXL | |
| SCHEMBL5562087 | 0.85 | SRC (0.55) | KDM1AEGFRSRCKDRAXL | |
| SCHEMBL5566389 | 0.85 | KDM1A (0.55) | KDM1AEGFRSRCKDRAXL | |
| SCHEMBL5564985 | 0.83 | SRC (0.55) | KDM1AEGFRSRCKDRFLT4 | |
| SCHEMBL5565947 | 0.80 | KDR (0.55) | KDM1AEGFRSRCKDRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262201-B1 | For the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals | ASTRAZENECA AB (SE) | 2007-08-28 | — | — | US | disclosed |
| EP-1119567-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-04 | — | — | EP | disclosed |
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |