Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 5/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5042765 | 0.97 | GRM5 (0.40) | GRM5HAO1GSK3BDYRK1AJAK2 | |
| SCHEMBL1175790 | 0.97 | GRM5 (0.40) | GRM5HAO1GSK3BDYRK1AJAK2 | |
| Formic Acid SCHEMBL5561468 | 0.93 | HAO1 (0.42) | GRM5HAO1GSK3BDYRK1A | |
| SCHEMBL5046343 | 0.90 | HAO1 (0.44) | GRM5HAO1GSK3BDYRK1A | |
| SCHEMBL1175808 | 0.90 | HAO1 (0.44) | GRM5HAO1GSK3BDYRK1A | |
| Formic Acid SCHEMBL5562022 | 0.85 | CHEK1 (0.38) | GRM5GSK3BDYRK1AJAK2JAK1 | |
| Formic Acid SCHEMBL5562752 | 0.85 | CHEK1 (0.38) | GRM5GSK3BDYRK1AJAK2JAK1 | |
| Formic Acid SCHEMBL5562423 | 0.85 | DYRK1A (0.40) | GRM5GSK3BDYRK1AJAK2JAK1 | |
| Formic Acid SCHEMBL5563840 | 0.84 | JAK2 (0.36) | GRM5GSK3BDYRK1AJAK2JAK1 | |
| Formic Acid SCHEMBL5562674 | 0.83 | GSK3B (0.46) | GRM5GSK3BDYRK1AJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697378-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2007-11-21 | — | — | EP | claimed |