Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5562497 | 0.88 | MEN1 (0.42) | MDM2MEN1KMT2ABRD4ATM | |
| SCHEMBL5555500 | 0.80 | MEN1 (0.47) | MDM2MEN1KMT2ABRD4ATM | |
| SCHEMBL5561754 | 0.78 | HTT (0.44) | MDM2ATMPGRTP53MAPT | |
| SCHEMBL11665099 | 0.78 | MEN1 (0.60) | MEN1KMT2ABRD4ATMTP53 | |
| SCHEMBL5555478 | 0.73 | PDE4A (0.41) | MDM2BRD4TP53MAPTGAA | |
| SCHEMBL16109476 | 0.71 | TP53 (0.47) | MDM2MEN1KMT2ABRD4ATM | |
| SCHEMBL9540152 | 0.69 | MEN1 (0.42) | MEN1KMT2ABRD4ATMPGR | |
| SCHEMBL5561611 | 0.66 | HTT (0.46) | MDM2MEN1KMT2AATMPGR | |
| SCHEMBL16109306 | 0.66 | GAA (0.60) | MEN1KMT2ABRD4TP53MAPT | |
| SCHEMBL11662300 | 0.65 | MEN1 (0.57) | MEN1KMT2ABRD4ATMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977750-B1 | FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES | JANSSEN PHARMACEUTICA NV (BE) | 2007-07-04 | — | — | EP | disclosed |
| US-6358961-B1 | ADMINISTERING QUINAZOLINE DERIVATIVE FOR INHIBITING TUMOR GROWTH IN MAMMALS | JANNSEN-CILAG S.A. (FR) | 2002-03-19 | — | — | US | disclosed |
| US-6177432-B1 | ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS | JANSSEN-CILAG S.A. (FR) | 2001-01-23 | — | — | US | disclosed |
| EP-0977750-A1 | FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049157-A1 | FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-11-05 | — | — | WO | disclosed |