Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 2/20 | 0.34 |
| ▸ | GRK6 | P43250 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | LHCGR | P22888 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5563801 | 1.00 | BACE1 (0.35) | BACE1LMNARXFP1MYCWDR5 | |
| SCHEMBL5563796 | 0.96 | BACE1 (0.36) | BACE1MYCWDR5CFTRGRK6 | |
| SCHEMBL27524700 | 0.81 | MAPT (0.37) | BACE1LMNAMYCWDR5TP53 | |
| SCHEMBL4419260 | 0.80 | BACE1 (0.41) | BACE1LMNARXFP1MYCWDR5 | |
| SCHEMBL4419266 | 0.80 | BACE1 (0.41) | BACE1LMNARXFP1MYCWDR5 | |
| SCHEMBL4419269 | 0.78 | GRK6 (0.41) | BACE1LMNARXFP1MYCWDR5 | |
| SCHEMBL27524703 | 0.77 | BACE1 (0.36) | BACE1LMNARXFP1MYCWDR5 | |
| SCHEMBL4427518 | 0.73 | MYC (0.46) | BACE1LMNARXFP1MYCWDR5 | |
| SCHEMBL27562261 | 0.73 | RXFP1 (0.41) | BACE1LMNARXFP1MYCWDR5 | |
| SCHEMBL4422399 | 0.72 | CYP1A2 (0.56) | LMNARXFP1MYCWDR5CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7229990-B2 | Bicyclic heteroaromatic compounds | N.V. ORGANON (NL) | 2007-06-12 | — | — | US | disclosed |