Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.56 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5557357 | 0.94 | GRM2 (0.69) | GRM2CYP3A4GRM3 | |
| SCHEMBL5562802 | 0.86 | GRM2 (0.73) | GRM2CYP3A4GRM3 | |
| SCHEMBL6486875 | 0.85 | CYP3A4 (0.77) | GRM2CYP3A4GRM3 | |
| SCHEMBL5557541 | 0.84 | CYP3A4 (0.73) | GRM2CYP3A4GRM3 | |
| SCHEMBL5564545 | 0.83 | GRM2 (0.63) | GRM2CYP3A4GRM3 | |
| SCHEMBL5557849 | 0.82 | CYP3A4 (0.74) | GRM2CYP3A4GRM3 | |
| SCHEMBL5557774 | 0.82 | GRM2 (0.88) | GRM2CYP3A4GRM3 | |
| SCHEMBL5563357 | 0.82 | GRM2 (0.67) | GRM2CYP3A4GRM3 | |
| SCHEMBL5562130 | 0.82 | GRM2 (0.67) | GRM2CYP3A4GRM3 | |
| SCHEMBL5556725 | 0.80 | GRM2 (0.71) | GRM2CYP3A4GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474416-B1 | DIHYDROBENZODIAZEPIN-2-ONE-DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | HOFFMANN LA ROCHE (CH) | 2007-09-26 | — | — | EP | disclosed |