Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569830 | 0.92 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL5565109 | 0.87 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL5567976 | 0.80 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL5567971 | 0.80 | MAPK13 (0.48) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL5567861 | 0.78 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL5567867 | 0.78 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL6876510 | 0.78 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| Hydrochloric Acid SCHEMBL5569497 | 0.77 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL5569154 | 0.77 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5568720 | 0.77 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480976-B1 | THIAZOLE DERIVATIVES AS NPY RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-09-19 | — | — | EP | disclosed |
| US-6686381-B2 | COMPOUNDS THAT ANTAGONIZE NEUROPEPTIDE Y AT THE Y5 RECEPTOR SUBTYPE REPRESENT AN APPROACH TO THE TREATMENT OF EATING DISORDERS SUCH AS OBESITY AND HYPERPHAGIA | HOFFMANN-LA ROCHE INC. | 2004-02-03 | — | — | US | disclosed |