Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 18/20 | 0.69 |
| ▸ | EGFR | P00533 | 9/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.69 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.66 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.66 |
| ▸ | FECH | P22830 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.51 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569993 | 0.89 | ERBB2 (0.71) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4385188 | 0.89 | ERBB2 (0.68) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL5566544 | 0.89 | ERBB2 (0.68) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL5635963 | 0.85 | ERBB2 (0.77) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL5635962 | 0.84 | ERBB2 (0.83) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL5636164 | 0.84 | ERBB2 (0.76) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL5567297 | 0.84 | ERBB2 (0.83) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4477486 | 0.84 | ERBB2 (0.66) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL5566561 | 0.84 | ERBB2 (0.82) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL5566476 | 0.84 | ERBB2 (0.82) | ERBB2EGFRKCNH2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756088-A1 | QUINAZOLINE DERIVATIVES AS ERBB RECEPTOR TYROSINE KINASES | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005118572-A1 | QUINAZOLINE DERIVATIVES AS ERBB RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2005-12-15 | — | — | WO | disclosed |