Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.65 |
| ▸ | SRC | P12931 | 3/20 | 0.65 |
| ▸ | EGFR | P00533 | 14/20 | 0.62 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.61 |
| ▸ | FLT1 | P17948 | 5/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.60 |
| ▸ | FLT4 | P35916 | 4/20 | 0.60 |
| ▸ | CSK | P41240 | 2/20 | 0.60 |
| ▸ | TEK | Q02763 | 2/20 | 0.60 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CIT | O14578 | 1/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5567635 | 0.92 | EGFR (0.68) | KDRSRCEGFREPHA2EPHB4 | |
| SCHEMBL5565975 | 0.90 | EGFR (0.68) | KDRSRCEGFREPHA2EPHB4 | |
| SCHEMBL5562091 | 0.90 | KDR (0.65) | KDRSRCEGFREPHA2EPHB4 | |
| Hydrochloric Acid SCHEMBL5566572 | 0.89 | KDR (0.64) | KDRSRCEGFREPHA2EPHB4 | |
| SCHEMBL5567690 | 0.89 | EGFR (0.73) | KDREGFR | |
| Hydrochloric Acid SCHEMBL6444589 | 0.88 | EGFR (0.72) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL5566528 | 0.85 | EGFR (0.61) | KDRSRCEGFREPHA2EPHB4 | |
| SCHEMBL5649175 | 0.79 | KDR (0.79) | KDRSRCEGFREPHA2EPHB4 | |
| SCHEMBL7882903 | 0.79 | KDR (0.47) | KDREGFREPHA2EPHB4ERBB2 | |
| Azm-475271 SCHEMBL29388701 | 0.79 | KDR (1.00) | KDRSRCEGFREPHA2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262201-B1 | For the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals | ASTRAZENECA AB (SE) | 2007-08-28 | — | — | US | disclosed |