Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6697361 | 0.97 | — | — | |
| SCHEMBL1294851 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL28509592 | 0.93 | — | — | |
| Dimethylamine SCHEMBL9461992 | 0.67 | — | — | |
| SCHEMBL25709616 | 0.67 | — | — | |
| SCHEMBL297923 | 0.67 | — | — | |
| SCHEMBL1435107 | 0.67 | — | — | |
| SCHEMBL9616257 | 0.67 | — | — | |
| SCHEMBL27280425 | 0.67 | — | — | |
| SCHEMBL6441976 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370265-B1 | HIV INHIBITING PYRAZINONE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2007-07-25 | — | — | EP | disclosed |
| US-7105522-B2 | HIV inhibiting pyrazinone derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-09-12 | — | — | US | disclosed |
| US-20040102456-A1 | Hiv inhibiting pyrazinone derivatives | K. U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2004-05-27 | — | — | US | disclosed |
| EP-1370265-A1 | HIV INHIBITING PYRAZINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002078708-A1 | HIV INHIBITING PYRAZINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-10-10 | — | — | WO | disclosed |