Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 5/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5567770 | 0.93 | MAPK13 (0.41) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL4267567 | 0.91 | MAPK13 (0.40) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL30197833 | 0.91 | MAPK13 (0.40) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL4174246 | 0.89 | MAPK13 (0.39) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL4174248 | 0.89 | MAPK13 (0.39) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL4181956 | 0.88 | MAPK14 (0.40) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL4181959 | 0.88 | MAPK14 (0.40) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL4186708 | 0.87 | MAPK13 (0.38) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL4186705 | 0.87 | MAPK13 (0.38) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL13853008 | 0.86 | MAPK14 (0.42) | MAPK13MAPK12MAPK11MAPK14KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868612-A2 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-12-26 | — | — | EP | claimed |
| WO-2006110298-A2 | 8-ALKYL/ARYL-4-ARYL-2-N- (ALKYLAMINO)-N'-SUBSTITUTED-N'-CYANOGUANIDINO-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE COMPOUNDS AND USE THEREOF | GLAXO GROUP LIMITED (GB) | 2006-10-19 | — | — | WO | claimed |