Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.64 |
| ▸ | GAK | O14976 | 1/20 | 0.63 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.60 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | INSR | P06213 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12743451 | 0.88 | EGFR (0.79) | EGFRERBB2GAKERBB4HDAC1 | |
| Hydrochloric Acid SCHEMBL1446356 | 0.87 | EGFR (0.78) | EGFRERBB2GAKERBB4HDAC1 | |
| SCHEMBL4031937 | 0.86 | EGFR (0.80) | EGFRERBB2GAKERBB4ERBB3 | |
| SCHEMBL6954367 | 0.85 | EGFR (0.80) | EGFRERBB2GAKERBB4ERBB3 | |
| SCHEMBL5567847 | 0.84 | EGFR (0.62) | EGFRERBB2ERBB4ERBB3 | |
| SCHEMBL5564412 | 0.83 | EGFR (0.76) | EGFRERBB2ERBB4 | |
| SCHEMBL1447185 | 0.83 | EGFR (0.66) | EGFRERBB2ERBB4INSRPDGFRB | |
| SCHEMBL3434524 | 0.82 | EGFR (0.75) | EGFRERBB2GAKERBB4ABL1 | |
| SCHEMBL27736360 | 0.82 | EGFR (0.64) | EGFRERBB2GAKERBB4ERBB3 | |
| SCHEMBL233913 | 0.82 | EGFR (0.77) | EGFRERBB2GAKERBB4ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070032508-A1 | Quinazoline derivatives as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | US | disclosed |
| EP-1664028-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026151-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032508-A1 | Quinazoline derivatives as tyrosine kinase inhibitors | ABL1, ERBB2, LCK | EGFR 15/4885ERBB2 2/4885GAK 289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.