Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | AHR | P35869 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13684350 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1AHRSLC22A2SLC22A1 | |
| SCHEMBL8341741 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2L3MBTL1AHRCHRM3MEN1 | |
| SCHEMBL18635470 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2L3MBTL1AHRCHRM3MEN1 | |
| SCHEMBL1856676 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2L3MBTL1AHRCHRM3MEN1 | |
| SCHEMBL23364963 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1AHRCHRM3MEN1 | |
| SCHEMBL29828412 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1AHRCHRM3MEN1 | |
| SCHEMBL30471943 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1AHRCHRM3MEN1 | |
| SCHEMBL20851528 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1CHRM3MEN1KMT2A | |
| SCHEMBL12717402 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1AHRCHRM3MEN1 | |
| SCHEMBL26835113 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1AHRCHRM3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546121-A4 | SUBSTITUTED TRIAZINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-15 | — | — | EP | disclosed |
| EP-1546121-A1 | SUBSTITUTED TRIAZINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004009562-A1 | SUBSTITUTED TRIAZINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, NV (BE) | 2004-01-29 | — | — | WO | disclosed |