Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.55 |
| ▸ | EPHA4 | P54764 | 2/20 | 0.55 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.55 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.55 |
| ▸ | EPHA5 | P54756 | 1/20 | 0.55 |
| ▸ | ADK | P55263 | 1/20 | 0.55 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | TEC | P42680 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569255 | 0.93 | EGFR (0.62) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL5569617 | 0.87 | EGFR (0.67) | EGFRERBB2EPHB4EPHA2 | |
| SCHEMBL1383188 | 0.84 | EGFR (1.00) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL5425187 | 0.84 | EGFR (1.00) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL5413663 | 0.81 | EGFR (0.94) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL5565280 | 0.81 | EGFR (0.66) | EGFRERBB2EPHB4EPHA2 | |
| Maleic Acid SCHEMBL5429639 | 0.80 | EGFR (0.92) | EGFRERBB2RIPK2RETEPHB2 | |
| Fumaric Acid SCHEMBL5429654 | 0.80 | EGFR (0.92) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL5564431 | 0.80 | EGFR (0.79) | EGFRERBB2KCNH2 | |
| SCHEMBL5564700 | 0.80 | EGFR (0.69) | EGFRERBB2EPHB4EPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070032508-A1 | Quinazoline derivatives as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032508-A1 | Quinazoline derivatives as tyrosine kinase inhibitors | ABL1, ERBB2, LCK | EGFR 15/4885ERBB2 2/4885RIPK2 789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.