Sugi Predict

Sugi Predict / Compounds / SCHEMBL5569844

SCHEMBL5569844

SCHEMBL5569844

COC(=O)c1cccc(CN(C2CCCCNC2=O)S(=O)(=O)c2ccc(Cl)cc2)c1.O=C1NCCCCC1N(Cc1cccc(C(=O)N2CCC(F)(F)CC2)c1)S(=O)(=O)c1ccc(Cl)cc1

nearest known ligand 0.61

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PSEN1 P49768 20/20 0.61
▸ PSEN2 P49810 20/20 0.61
▸ APH1B Q8WW43 20/20 0.61
▸ NCSTN Q92542 20/20 0.61
▸ APH1A Q96BI3 20/20 0.61
▸ PSENEN Q9NZ42 20/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5620501 0.94 PSEN1 (0.66) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL5567860 0.90 PSEN1 (0.64) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL5517863 0.89 PSEN1 (0.75) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL5510359 0.89 PSEN1 (0.75) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL5563860 0.87 PSEN1 (0.69) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL5567740 0.87 PSEN1 (0.63) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL5568825 0.86 PSEN1 (0.69) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL5562303 0.86 PSEN1 (0.57) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL5619528 0.82 PSEN1 (0.61) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL5620039 0.81 PSEN1 (0.59) PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1768960-A1 SULFONAMIDE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2007-04-04 — — EP disclosed
WO-2006005486-A1 SULFONAMIDE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2006-01-19 — — WO disclosed