SCHEMBL5570090

SCHEMBL5570090

CCCC(=O)c1cc(C)cc(C)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B3 P37058 2/20 0.52
TPMT P51580 1/20 0.50
HPGD P15428 4/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
ALDH1A1 P00352 2/20 0.45
ALOX15 P16050 1/20 0.45
TSHR P16473 1/20 0.45
RECQL P46063 1/20 0.45
HSD17B10 Q99714 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
KMT2A Q03164 1/20 0.41
STS P08842 1/20 0.41
PTGS1 P23219 2/20 0.40
PTGS2 P35354 2/20 0.40
ALOX5 P09917 1/20 0.40
MAPT P10636 1/20 0.39
RAB9A P51151 1/20 0.39
HCAR1 Q9BXC0 1/20 0.39
FASN P49327 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30089552 0.88 TPMT (0.56) TPMTHPGDALDH1A1KMT2AHCAR1
SCHEMBL7878110 0.88 TPMT (0.59) HSD17B3TPMTHPGDSMN1; SMN2L3MBTL1
SCHEMBL5567306 0.85 HSD17B3 (0.56) HSD17B3HTR7
SCHEMBL5570402 0.84 HSD17B3 (0.58) HSD17B3ALDH1A1KMT2AMAPT
SCHEMBL9720617 0.81 TPMT (0.54) TPMTHPGDSMN1; SMN2L3MBTL1TSHR
SCHEMBL5084680 0.80 KMT2A (0.64) TPMTHPGDSMN1; SMN2L3MBTL1ALDH1A1
SCHEMBL13812080 0.80 TPMT (0.48) TPMTHPGDALDH1A1KMT2AHCAR1
SCHEMBL14139168 0.80 TPMT (0.48) TPMTHPGDKMT2AHCAR1
SCHEMBL2027904 0.79 CTNNB1 (0.59) HSD17B3HPGDSMN1; SMN2L3MBTL1ALDH1A1
SCHEMBL10600090 0.78 HSD17B3 (0.53) HSD17B3HPGDSMN1; SMN2L3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1745004-B1 ARYL KETONE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS EMISPHERE TECH INC (US) 2016-05-18 EP disclosed
EP-1745004-A4 ARYL KETONE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS EMISPHERE TECH INC (US) 2007-05-09 EP disclosed
EP-1745004-A2 ARYL KETONE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS Emisphere Technologies, Inc. (US) 2007-01-24 EP disclosed
WO-2005117854-A2 ARYL KETONE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS EMISPHERE TECHNOLOGIES, INC. (US) 2005-12-15 WO disclosed