Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 14/20 | 0.57 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5574198 | 0.85 | PDE10A (0.51) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| SCHEMBL4159799 | 0.85 | PDE10A (0.78) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| SCHEMBL5574215 | 0.84 | PDE10A (0.56) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| SCHEMBL4146861 | 0.83 | PDE10A (0.80) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| SCHEMBL4147718 | 0.77 | PDE10A (0.54) | PDE10ALGALS3PDE4D | |
| SCHEMBL3269898 | 0.77 | PDE10A (0.78) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| SCHEMBL30123678 | 0.77 | PDE10A (0.78) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| SCHEMBL4153869 | 0.74 | PDE10A (0.79) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| Mardepodect SCHEMBL29496270 | 0.73 | PDE10A (1.00) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| SCHEMBL3271928 | 0.73 | PDE10A (1.00) | PDE10ALGALS3PDE4DPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129183-A2 | BICYCLIC HETEROARYL COMPOUNDS AS PDE10 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | claimed |