Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 16/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4914465 | 0.78 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL4914472 | 0.78 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL5572488 | 0.77 | MDM2 (0.42) | MDM2 | |
| SCHEMBL12083839 | 0.75 | MDM2 (0.94) | MDM2TP53 | |
| SCHEMBL4910299 | 0.75 | MDM2 (0.94) | MDM2TP53 | |
| SCHEMBL12017325 | 0.74 | MDM2 (0.84) | MDM2TP53 | |
| SCHEMBL4911245 | 0.74 | MDM2 (0.84) | MDM2TP53 | |
| SCHEMBL8273099 | 0.74 | MDM2 (0.69) | MDM2TP53 | |
| SCHEMBL8272761 | 0.71 | MDM2 (0.86) | MDM2TP53 | |
| SCHEMBL4912491 | 0.70 | MDM2 (0.79) | MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786773-A1 | ISOINDOLIN-1-ONE DERIVATIVES | Cancer Research Technology Limited (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024837-A1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |