Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 18/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 18/20 | 0.76 |
| ▸ | SLC6A3 | Q01959 | 17/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4302124 | 0.87 | SLC6A2 (0.77) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4302131 | 0.86 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4308536 | 0.86 | SLC6A2 (0.76) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4317608 | 0.86 | SLC6A2 (0.76) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4313447 | 0.84 | SLC6A4 (0.72) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4455109 | 0.83 | SLC6A4 (0.71) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4301931 | 0.83 | SLC6A4 (0.71) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4317129 | 0.83 | SLC6A2 (0.71) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4307020 | 0.82 | SLC6A2 (0.69) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4456866 | 0.82 | SLC6A2 (0.69) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778639-A2 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR Technology, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020049-A2 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR TECHNOLOGY, INC. (US) | 2006-02-23 | — | — | WO | disclosed |