Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | DRD4 | P21917 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5572391 | 0.87 | HSD17B10 (0.41) | HSD17B10TSHRALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL5572387 | 0.86 | CYP2D6 (0.42) | HSD17B10TSHRALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL5571645 | 0.86 | CYP2D6 (0.42) | HSD17B10TSHRALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL5571843 | 0.83 | HRH3 (0.42) | HSD17B10ALDH1A1CYP2D6CYP1A2ALOX15 | |
| SCHEMBL2700657 | 0.78 | HCRTR2 (0.35) | HSD17B10TSHRALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL550861 | 0.78 | HCRTR2 (0.35) | HSD17B10TSHRALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL551542 | 0.78 | HCRTR2 (0.35) | HSD17B10TSHRALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL550860 | 0.78 | HCRTR2 (0.35) | HSD17B10TSHRALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL551541 | 0.78 | HCRTR2 (0.35) | HSD17B10TSHRALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL2700655 | 0.78 | HCRTR2 (0.35) | HSD17B10TSHRALDH1A1CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006053024-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-05-18 | — | — | WO | claimed |