Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 20/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 7/20 | 1.00 |
| ▸ | EGFR | P00533 | 8/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5635979 | 1.00 | ERBB2 (1.00) | ERBB2KCNH2EGFR | |
| SCHEMBL5634939 | 0.93 | ERBB2 (0.88) | ERBB2KCNH2EGFR | |
| SCHEMBL5568342 | 0.93 | ERBB2 (0.88) | ERBB2KCNH2EGFR | |
| SCHEMBL5570471 | 0.92 | ERBB2 (0.85) | ERBB2KCNH2EGFR | |
| SCHEMBL5637026 | 0.92 | ERBB2 (0.85) | ERBB2KCNH2EGFR | |
| SCHEMBL5636565 | 0.90 | ERBB2 (0.82) | ERBB2KCNH2EGFR | |
| SCHEMBL5635649 | 0.90 | ERBB2 (0.81) | ERBB2KCNH2EGFR | |
| SCHEMBL5566608 | 0.88 | ERBB2 (0.79) | ERBB2KCNH2EGFR | |
| SCHEMBL5635992 | 0.88 | ERBB2 (0.79) | ERBB2KCNH2EGFR | |
| SCHEMBL5569876 | 0.88 | ERBB2 (0.79) | ERBB2KCNH2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756088-A1 | QUINAZOLINE DERIVATIVES AS ERBB RECEPTOR TYROSINE KINASES | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005118572-A1 | QUINAZOLINE DERIVATIVES AS ERBB RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2005-12-15 | — | — | WO | disclosed |