Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 19/20 | 0.62 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5572393 | 0.91 | CXCR2 (0.58) | CXCR2CXCR1 | |
| SCHEMBL1487221 | 0.91 | CXCR2 (0.60) | CXCR2CXCR1ADORA3 | |
| SCHEMBL1486995 | 0.90 | CXCR2 (0.58) | CXCR2CXCR1 | |
| SCHEMBL1487072 | 0.90 | CXCR2 (0.72) | CXCR2CXCR1 | |
| SCHEMBL1487304 | 0.90 | CXCR2 (0.66) | CXCR2CXCR1 | |
| SCHEMBL1487295 | 0.87 | CXCR2 (0.63) | CXCR2CXCR1 | |
| SCHEMBL1487836 | 0.86 | CXCR2 (0.63) | CXCR2CXCR1ADORA3 | |
| SCHEMBL1487429 | 0.85 | CXCR2 (0.60) | CXCR2CXCR1ADORA3 | |
| SCHEMBL1487398 | 0.84 | CXCR2 (0.61) | CXCR2CXCR1 | |
| SCHEMBL1487319 | 0.84 | CXCR2 (0.61) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809624-A1 | PYRIMIDINE SULPHONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006024823-A1 | PYRIMIDINE SULPHONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-03-09 | — | — | WO | disclosed |