Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 16/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | CCR7 | P32248 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5572655 | 1.00 | CXCR2 (0.46) | CXCR2CXCR1ADORA3CCR7RXRA | |
| SCHEMBL1487377 | 0.84 | CXCR2 (0.49) | CXCR2CXCR1CCR7 | |
| SCHEMBL1487129 | 0.83 | CXCR2 (0.47) | CXCR2CXCR1CCR7RXRARXRB | |
| SCHEMBL5569651 | 0.83 | CXCR2 (0.47) | CXCR2CXCR1CCR7RXRARXRB | |
| SCHEMBL1487135 | 0.83 | CXCR2 (0.47) | CXCR2CXCR1CCR7RXRARXRB | |
| SCHEMBL1487350 | 0.82 | CXCR2 (0.45) | CXCR2CXCR1CCR7 | |
| SCHEMBL5569979 | 0.82 | CXCR2 (0.54) | CXCR2CXCR1CCR7 | |
| SCHEMBL1487098 | 0.82 | CXCR2 (0.54) | CXCR2CXCR1CCR7 | |
| SCHEMBL1487190 | 0.82 | CXCR2 (0.54) | CXCR2CXCR1CCR7 | |
| SCHEMBL1487119 | 0.82 | CXCR2 (0.42) | CXCR2CXCR1ADORA3CCR7RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809624-A1 | PYRIMIDINE SULPHONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006024823-A1 | PYRIMIDINE SULPHONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-03-09 | — | — | WO | disclosed |