Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 17/20 | 0.67 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.62 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.62 |
| ▸ | LTK | P29376 | 1/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.62 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.62 |
| ▸ | CDK8 | P49336 | 1/20 | 0.62 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.62 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.62 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.62 |
| ▸ | FBP1 | P09467 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL4960121 | 0.98 | ADORA1 (0.69) | ADORA1CHEK1DAPK3LTKMAPK8 | |
| SCHEMBL30953664 | 0.91 | ADORA1 (0.67) | ADORA1CHEK1DAPK3LTKMAPK8 | |
| SCHEMBL1801705 | 0.86 | ADORA1 (0.63) | ADORA1CHEK1DAPK3LTKMAPK8 | |
| Iodide SCHEMBL3994778 | 0.83 | ADORA1 (0.84) | ADORA1 | |
| SCHEMBL6191569 | 0.81 | ADORA1 (0.50) | ADORA1CHEK1DAPK3LTKMAPK8 | |
| Iodide SCHEMBL3994666 | 0.80 | ADORA1 (1.00) | ADORA1 | |
| Iodide SCHEMBL3989408 | 0.80 | ADORA1 (0.64) | ADORA1CHEK1DAPK3LTKMAPK8 | |
| Hydrochloric Acid SCHEMBL7895436 | 0.80 | ADORA1 (0.49) | ADORA1CHEK1DAPK3LTKMAPK8 | |
| Iodide SCHEMBL3989936 | 0.80 | ADORA1 (0.83) | ADORA1CHEK1DAPK3LTKMAPK8 | |
| SCHEMBL30953685 | 0.80 | KDM4E (0.64) | ADORA1FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791822-A1 | SUBSTITUTED N-ACYL-2-AMINOTHIAZOLES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006013054-A1 | SUBSTITUTED N-ACYL-2-AMINOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | WO | disclosed |
| EP-1173176-B1 | UTILIZATION OF POLYCYCLIC 2-AMINO-THIAZOLE SYSTEMS IN THE PRODUCTION OF MEDICAMENTS FOR PROPHYLAXIS OR TREATMENT OF OBESITY | AVENTIS PHARMA GMBH (DE) | 2004-05-26 | — | — | EP | disclosed |
| US-6476059-B1 | Use of polycyclic 2-aminothiazole systems for the treatment of obesity | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-11-05 | — | — | US | disclosed |
| EP-1173176-A1 | UTILIZATION OF POLYCYCLIC 2-AMINO-THIAZOLE SYSTEMS IN THE PRODUCTION OF MEDICAMENTS FOR PROPHYLAXIS OR TREATMENT OF OBESITY | Aventis Pharma Deutschland GmbH (DE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000051602-A1 | UTILIZATION OF POLYCYCLIC 2-AMINO-THIAZOLE SYSTEMS IN THE PRODUCTION OF MEDICAMENTS FOR PROPHYLAXIS OR TREATMENT OF OBESITY | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-09-08 | — | — | WO | disclosed |