Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 19/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 19/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 18/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4303865 | 0.87 | SLC6A4 (0.53) | SLC6A4SLC6A3SLC6A2HRH4 | |
| SCHEMBL4310335 | 0.86 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL4310386 | 0.86 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2HRH4 | |
| SCHEMBL4306991 | 0.84 | SLC6A4 (0.54) | SLC6A4SLC6A3SLC6A2HRH4 | |
| SCHEMBL4306429 | 0.84 | SLC6A4 (0.48) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL4306728 | 0.84 | SLC6A4 (0.65) | SLC6A4SLC6A3SLC6A2HRH4 | |
| SCHEMBL4309427 | 0.81 | SLC6A2 (0.61) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL4310233 | 0.81 | SLC6A2 (0.57) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL4306436 | 0.80 | SLC6A2 (0.51) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL4312773 | 0.80 | SLC6A2 (0.62) | SLC6A4SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778639-A2 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR Technology, Inc. (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020049-A2 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR TECHNOLOGY, INC. (US) | 2006-02-23 | — | — | WO | claimed |