⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992571 | 0.90 | — | — | |
| SCHEMBL12028099 | 0.76 | — | — | |
| SCHEMBL6424030 | 0.76 | HIF1A (0.33) | — | |
| SCHEMBL235514 | 0.68 | — | — | |
| SCHEMBL10375194 | 0.65 | — | — | |
| SCHEMBL108935 | 0.63 | — | — | |
| SCHEMBL570870 | 0.56 | — | — | |
| SCHEMBL515026 | 0.56 | — | — | |
| SCHEMBL1781839 | 0.55 | HIF1A (0.50) | — | |
| Piperazine SCHEMBL1091869 | 0.55 | HIF1A (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434594-A4 | CYCLOSPORIN ANALOGS FOR THE TREATMENT OF AUTOIMMUNE DISEASES | ENANTA PHARM INC (US) | 2006-05-10 | — | — | EP | claimed |
| EP-1434594-A1 | CYCLOSPORIN ANALOGS FOR THE TREATMENT OF AUTOIMMUNE DISEASES | Enanta Pharmaceuticals, Inc. (US) | 2004-07-07 | — | — | EP | claimed |
| US-20030104992-A1 | Cyclosporin analogs for the treatment of autoimmune diseases | ENANTA PHARMACEUTICALS, INC. | 2003-06-05 | — | — | US | claimed |
| WO-2003033010-A1 | CYCLOSPORIN ANALOGS FOR THE TREATMENT OF AUTOIMMUNE DISEASES | ENANTA PHARMACEUTICALS, INC. (US) | 2003-04-24 | — | — | WO | claimed |
| US-7226906-B2 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | ARRAY BIOPHARMA, INC. (US) | 2007-06-05 | — | — | US | disclosed |
| EP-1434594-A4 | CYCLOSPORIN ANALOGS FOR THE TREATMENT OF AUTOIMMUNE DISEASES | ENANTA PHARM INC (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2006023452-A2 | CYCLOSPORIN ANALOGS FOR THE TREATMENT OF IMMUNOREGULATORY DISORDERS AND RESPIRATORY DISEASES | ARRAY BIOPHARMA INC. (US) | 2006-03-02 | — | — | WO | disclosed |
| US-20060035821-A1 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | ARRAY BIOPHARMA INC. | 2006-02-16 | — | — | US | disclosed |
| US-20060035822-A1 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | ARRAY BIOPHARMA INC. | 2006-02-16 | — | — | US | disclosed |
| US-6809077-B2 | A CYCLIC POLYPEPTIDES; IMMUNOSUPPRESSIVE ANTI-INFLAMMATORY ACTIVITY, INHIBITING ANTIGEN-INDUCED INFLAMMATORY CELL INFILTRATION | ENANTA PHARMACEUTICALS, INC. | 2004-10-26 | — | — | US | disclosed |
| EP-1434594-A1 | CYCLOSPORIN ANALOGS FOR THE TREATMENT OF AUTOIMMUNE DISEASES | Enanta Pharmaceuticals, Inc. (US) | 2004-07-07 | — | — | EP | disclosed |
| US-20030109425-A1 | Cyclosporin analogs for the treatment of lung diseases | ENANTA PHARMACEUTICALS, INC. | 2003-06-12 | — | — | US | disclosed |
| US-20030104992-A1 | Cyclosporin analogs for the treatment of autoimmune diseases | ENANTA PHARMACEUTICALS, INC. | 2003-06-05 | — | — | US | disclosed |
| US-20030087813-A1 | Cyclosporin analogs for the treatment of lung diseases | ENANTA PHARMACEUTICALS, INC. | 2003-05-08 | — | — | US | disclosed |
| WO-2003033010-A1 | CYCLOSPORIN ANALOGS FOR THE TREATMENT OF AUTOIMMUNE DISEASES | ENANTA PHARMACEUTICALS, INC. (US) | 2003-04-24 | — | — | WO | disclosed |
| WO-2003030834-A2 | CYCLOSPORIN ANALOGS FOR THE TREATMENT OF LUNG DISEASES | ENANTA PHARMACEUTICALS, INC. (US) | 2003-04-17 | — | — | WO | disclosed |