Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | DPP4 | P27487 | 3/20 | 0.53 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.53 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.40 |
| ▸ | GRM8 | O00222 | 1/20 | 0.37 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28528076 | 1.00 | BLM (0.56) | BLMALOX15PMP22KMT2ADPP4 | |
| SCHEMBL8773315 | 0.91 | BLM (0.60) | BLMALOX15PMP22KMT2ADPP4 | |
| SCHEMBL5574084 | 0.85 | GRM8 (0.56) | BLMALOX15PMP22KMT2ADPP4 | |
| SCHEMBL31572013 | 0.85 | BLM (0.59) | BLMALOX15PMP22KMT2ADPP4 | |
| SCHEMBL5574080 | 0.85 | GRM8 (0.56) | BLMALOX15PMP22KMT2ADPP4 | |
| SCHEMBL3424069 | 0.82 | DPP4 (0.57) | BLMALOX15PMP22KMT2ADPP4 | |
| SCHEMBL29833669 | 0.80 | BLM (0.58) | BLMALOX15PMP22KMT2ADPP4 | |
| SCHEMBL288407 | 0.80 | BLM (0.58) | BLMALOX15PMP22KMT2ADPP4 | |
| SCHEMBL21447963 | 0.80 | BLM (0.58) | BLMALOX15PMP22KMT2ADPP4 | |
| SCHEMBL4321248 | 0.80 | BLM (0.58) | BLMALOX15PMP22KMT2ADPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111295389-B | Bioactive substance conjugate and preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2021-10-22 | — | — | CN | claimed |
| EP-0708660-A1 | PRODRUGS OF PROTEIN TYROSINE KINASE INHIBITORS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1996-05-01 | — | — | EP | claimed |
| WO-1995002420-A2 | PRODRUGS OF PROTEIN TYROSINE KINASE INHIBITORS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LTD. (GB) | 1995-01-26 | — | — | WO | claimed |
| CN-113453720-B | Dual ligand drug conjugate and uses thereof | 同宜医药（苏州）有限公司 | 2025-05-06 | — | — | CN | disclosed |
| CN-119031938-A | Compounds and uses | 同宜医药（苏州）有限公司 | 2024-11-26 | — | — | CN | disclosed |
| CN-113549127-A | Vincristine and antibody conjugate thereof, preparation method and medical application thereof | 上海翰森生物医药科技有限公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-112341521-A | Small molecule active compound and antibody conjugate thereof, preparation method and medical application thereof | 上海翰森生物医药科技有限公司 | 2021-02-09 | — | — | CN | disclosed |
| EP-0711177-B1 | IMPROVEMENTS RELATING TO THE PREPARATION OF PRODRUGS | CANCER RES CAMPAIGN TECH (GB) | 2007-05-09 | — | — | EP | disclosed |
| EP-0708660-B1 | COMPOUNDS USEFUL FOR PREPARING PRODRUGS OF PROTEIN TYROSINE KINASE INHIBITORS | CANCER RES CAMPAIGN TECH (GB) | 2007-05-09 | — | — | EP | disclosed |
| US-5770731-A | PROTECTING GROUPS, ANTIBODY DIRECTED ENZYME/PRODRUG THERAPY, ANTICARCINOGENIC AGENTS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1998-06-23 | — | — | US | disclosed |
| US-5728868-A | Prodrugs of protein tyrosine kinase inhibitors | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |