SCHEMBL5574698

SCHEMBL5574698

Nc1nc(=O)[nH]cc1C1O[C@H](CO)[C@@H](O)[C@@H]1O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNP P00491 6/20 0.47
HIF1A Q16665 2/20 0.40
LMNA P02545 4/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
MTOR P42345 2/20 0.40
ALDH1A1 P00352 2/20 0.40
GMNN O75496 2/20 0.40
NFKB1 P19838 2/20 0.40
BLM P54132 2/20 0.40
PMP22 Q01453 2/20 0.40
UMPS P11172 1/20 0.40
THRB P10828 1/20 0.40
MDM2 Q00987 1/20 0.40
NCOA1 Q15788 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.40
POLB P06746 1/20 0.40
TP53 P04637 1/20 0.40
DNMT1 P26358 1/20 0.40
THPO P40225 1/20 0.40
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL466334 1.00 PNP (0.47) PNPHIF1ALMNASMN1; SMN2MTOR
SCHEMBL4588335 1.00 PNP (0.47) PNPHIF1ALMNASMN1; SMN2MTOR
SCHEMBL2778662 1.00 PNP (0.47) PNPHIF1ALMNASMN1; SMN2MTOR
SCHEMBL5574710 1.00 PNP (0.47) PNPHIF1ALMNASMN1; SMN2MTOR
SCHEMBL29122970 0.99 PNP (0.46) PNPHIF1APYGL
SCHEMBL17873225 0.82 PNP (0.44) PNPHIF1ALMNASMN1; SMN2ALDH1A1
SCHEMBL14365990 0.81 PNP (0.50) PNPHIF1ALMNASMN1; SMN2MTOR
SCHEMBL10081193 0.81 PNP (0.50) PNPHIF1ALMNASMN1; SMN2MTOR
SCHEMBL14066117 0.81 PNP (0.50) PNPHIF1ALMNASMN1; SMN2MTOR
SCHEMBL902517 0.81 PNP (0.50) PNPHIF1ALMNASMN1; SMN2MTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070015723-A1 Antiviral oligonucleotides having a conserved G4 core sequence ISIS PHARMACEUTICALS, INC. 2007-01-18 US disclosed
EP-0672193-B1 USE OF OLIGONUCLEOTIDES HAVING A CONSERVED G 4 CORE SEQUENCE FOR THE PREPARATION OF A MEDICAMENT ISIS PHARMACEUTICALS INC (US) 2002-08-14 EP disclosed
US-6310044-B1 ANTISENSE PHOSPHORTHIOATE OR METHYLPHOSPHONATE OLIGONUCLEOTIDES OF GIVEN SEQUENCE, COMPLEMENTARY TO A TRANSLATION INITIATION PORTION OF MRNA FROM A HERPES VIRUS OPEN READING FRAME ISIS PHARMACEUTICALS, INC. 2001-10-30 US disclosed
EP-1016715-A1 Oligonucleotides having a conserved G4 core sequence ISIS PHARMACEUTICALS, INC. (US) 2000-07-05 EP disclosed
US-5952490-A A CHEMICALLY MODIFIED OLIGONUCLEOTIDE THAT INHIBITS VIRAL ACTIVITY OR PHOSPHOLIPASE A; TREATMENT OF AGING AND MALIGNANT CELL GROWTH ISIS PHARMACEUTICALS, INC. (US) 1999-09-14 US disclosed
EP-0517859-B1 OLIGONUCLEOTIDE THERAPIES FOR MODULATING THE EFFECTS OF HERPESVIRUSES ISIS PHARMACEUTICALS INC (US) 1998-07-22 EP disclosed
US-5658891-A CONTACTING CELLS OF EYE WITH ANTIBODY ISIS PHARMACEUTICALS, INC. 1997-08-19 US disclosed
US-5514577-A TREATMENT OF HERPES VIRUS WITH OLIGONUCLEOTIDES AS VIRICIDES ISIS PHARMACEUTICALS, INC. (US) 1996-05-07 US disclosed
EP-0692930-A1 OLIGONUCLEOTIDE THERAPIES FOR MODULATING THE EFFECTS OF HERPESVIRUSES ISIS PHARMACEUTICALS, INC. (US) 1996-01-24 EP disclosed
EP-0672193-A1 OLIGONUCLEOTIDES HAVING A CONSERVED G 4? CORE SEQUENCE ISIS PHARMACEUTICALS, INC. (US) 1995-09-20 EP disclosed
WO-1994019945-A1 OLIGONUCLEOTIDE THERAPIES FOR MODULATING THE EFFECTS OF HERPESVIRUSES ISIS PHARMACEUTICALS, INC. (US) 1994-09-15 WO disclosed
WO-1994008053-A1 OLIGONUCLEOTIDES HAVING A CONSERVED G4 CORE SEQUENCE ISIS PHARMACEUTICALS, INC. (US) 1994-04-14 WO disclosed
US-5248670-A Phosphorothioate internucleotide bonds ISIS PHARMACEUTICALS, INC. (US) 1993-09-28 US disclosed
EP-0517859-A1 OLIGONUCLEOTIDE THERAPIES FOR MODULATING THE EFFECTS OF HERPESVIRUSES ISIS PHARMACEUTICALS, INC. (US) 1992-12-16 EP disclosed
WO-1991012811-A1 OLIGONUCLEOTIDE THERAPIES FOR MODULATING THE EFFECTS OF HERPESVIRUSES ISIS PHARMACEUTICALS, INC. (US) 1991-09-05 WO disclosed