SCHEMBL557534

SCHEMBL557534

CC(C)n1c(/C=C/[C@H](O)C[C@H](O)CC(=O)OC(C)(C)C)c(-c2ccc(F)cc2)c2ccccc21

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 6/20 0.79
CYP2C9 P11712 4/20 0.79
SIRT6 Q8N6T7 2/20 0.79
NR4A2 P43354 2/20 0.79
PDE4D Q08499 2/20 0.79
ABCC3 O15438 1/20 0.79
ABCB11 O95342 1/20 0.79
PGR P06401 1/20 0.79
ADORA3 P0DMS8 1/20 0.79
RXRA P19793 1/20 0.79
TBXA2R P21731 1/20 0.79
CCKAR P32238 1/20 0.79
ADRA1A P35348 1/20 0.79
PTGS2 P35354 1/20 0.79
SLC10A1 Q14973 1/20 0.79
KDM4E B2RXH2 1/20 0.75
ALDH1A1 P00352 1/20 0.75
LMNA P02545 1/20 0.75
CYP1A2 P05177 1/20 0.75
SMN1; SMN2 Q16637 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL557746 1.00 HMGCR (0.79) HMGCRCYP2C9SIRT6NR4A2PDE4D
SCHEMBL556017 1.00 HMGCR (0.79) HMGCRCYP2C9SIRT6NR4A2PDE4D
SCHEMBL556712 1.00 HMGCR (0.79) HMGCRCYP2C9SIRT6NR4A2PDE4D
SCHEMBL4905705 1.00 HMGCR (0.79) HMGCRCYP2C9SIRT6NR4A2PDE4D
SCHEMBL4905717 1.00 HMGCR (0.79) HMGCRCYP2C9SIRT6NR4A2PDE4D
SCHEMBL557747 1.00 HMGCR (0.79) HMGCRCYP2C9SIRT6NR4A2PDE4D
SCHEMBL31517689 0.92 HMGCR (0.66) HMGCRCYP2C9SIRT6NR4A2PDE4D
SCHEMBL31517670 0.92 HMGCR (0.66) HMGCRCYP2C9SIRT6NR4A2PDE4D
SCHEMBL31517758 0.91 HMGCR (0.65) HMGCRCYP2C9SIRT6NR4A2PDE4D
SCHEMBL31517725 0.91 HMGCR (0.65) HMGCRCYP2C9SIRT6NR4A2PDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2419407-B1 IMPROVED PROCESS FOR THE PREPARATION OF FLUVASTATIN AND SALTS THEREOF PHARMATHEN SA (GR) 2012-11-14 EP claimed
EP-2419407-A1 IMPROVED PROCESS FOR THE PREPARATION OF FLUVASTATIN AND SALTS THEREOF Pharmathen S.A. (GR) 2012-02-22 EP claimed
US-20120035374-A1 PROCESS FOR THE PREPARATION OF FLUVASTATIN AND SALTS THEREOF PHARMATHEN S.A. (GR) 2012-02-09 US claimed
WO-2010118757-A1 IMPROVED PROCESS FOR THE PREPARATION OF FLUVASTATIN AND SALTS THEREOF PHARMATHEN S.A. (GR) 2010-10-21 WO claimed
US-8835486-B2 Pharmaceutical formulation containing an HMG-COA reductase inhibitor and method for the preparation thereof PHARMATHEN S.A. (GR) 2014-09-16 US disclosed
CN-101250153-B Technique for preparing fluvastatin sodium crystal system SHENZHEN SALUBRIS PHARM CO LTD 2013-09-18 CN disclosed
EP-1928425-B1 Pharmaceutical formulation containing fluvastatin PHARMATHEN SA (GR) 2013-01-23 EP disclosed
EP-2419407-B1 IMPROVED PROCESS FOR THE PREPARATION OF FLUVASTATIN AND SALTS THEREOF PHARMATHEN SA (GR) 2012-11-14 EP disclosed
EP-2419407-A1 IMPROVED PROCESS FOR THE PREPARATION OF FLUVASTATIN AND SALTS THEREOF Pharmathen S.A. (GR) 2012-02-22 EP disclosed
US-20120035374-A1 PROCESS FOR THE PREPARATION OF FLUVASTATIN AND SALTS THEREOF PHARMATHEN S.A. (GR) 2012-02-09 US disclosed
WO-2010118757-A1 IMPROVED PROCESS FOR THE PREPARATION OF FLUVASTATIN AND SALTS THEREOF PHARMATHEN S.A. (GR) 2010-10-21 WO disclosed
US-20100137400-A1 PHARMACEUTICAL FORMULATION CONTAINING AN HMG-COA REDUCTASE INHIBITOR AND METHOD FOR THE PREPARATION THEREOF PHARMATHEN S.A. (GR) 2010-06-03 US disclosed
WO-2006109147-A1 SUBSTANTIALLY PURE AMORPHOUS FLUVASTATIN, PROCESSES FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME GLENMARK PHARMACEUTICALS LIMITED (US) 2006-10-19 WO disclosed
EP-1667968-A1 PROCESSES FOR THE PREPARATION OFA POLYMORPH OF FLUVASTATIN SODIUM Teva Pharmaceutical Industries Limited (IL) 2006-06-14 EP disclosed
EP-1638937-A2 FLUVASTATIN SODIUM CRYSTAL FORMS XIV, LXXIII,LXXIX, LXXX AND LXXXVII, PROCESSES FOR PREPARING THEM, COMPOSITIONS CONTAINING THEM AND METHODS OF USING THEM Teva Pharmaceutical Industries Limited (IL) 2006-03-29 EP disclosed
WO-2006030304-A2 NOVEL FORMS OF FLUVASTATIN SODIUM, PROCESSES FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF RANBAXY LABORATORIES LIMITED (IN) 2006-03-23 WO disclosed
US-20050119342-A1 Process for the preparation of fluvastatin sodium crystal form XIV TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2005-06-02 US disclosed
WO-2005040113-A1 PROCESSES FOR THE PREPARATION OF A POLYMORPH OF FLUVASTATIN SODIUM TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2005-05-06 WO disclosed
US-20050038114-A1 Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2005-02-17 US disclosed
WO-2004113291-A2 FLUVASTATIN SODIUM CRYSTAL FORMS XIV, LXXIII,LXXIX, LXXX AND LXXXVII, PROCESSES FOR PREPARING THEM, COMPOSITIONS CONTAINING THEM AND METHODS OF USING THEM TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2004-12-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050038114-A1 Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them LPXN, PCSK9, CYP4A11 HMGCR 8/4885CYP2C9 27/4885SIRT6 1568/4885
US-20120035374-A1 PROCESS FOR THE PREPARATION OF FLUVASTATIN AND SALTS THEREOF HMGCR, CETP, PCSK9 HMGCR 1/4885CYP2C9 61/4885SIRT6 1760/4885
US-20050119342-A1 Process for the preparation of fluvastatin sodium crystal form XIV CYP4F11, CYP4A11, CYP4F3 HMGCR 5/4885CYP2C9 23/4885SIRT6 2721/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.