Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 14/20 | 0.67 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.59 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5571761 | 0.84 | TNFRSF1A (0.81) | TNFRSF1AABCG2CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL5571769 | 0.84 | TNFRSF1A (0.81) | TNFRSF1AABCG2CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL5571808 | 0.83 | TNFRSF1A (0.74) | TNFRSF1AABCG2 | |
| SCHEMBL5571805 | 0.83 | TNFRSF1A (0.74) | TNFRSF1AABCG2 | |
| SCHEMBL6112015 | 0.82 | TNFRSF1A (0.72) | TNFRSF1AABCG2CYP3A4TP53 | |
| SCHEMBL5575691 | 0.82 | TNFRSF1A (0.72) | TNFRSF1AABCG2CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL5571674 | 0.81 | TNFRSF1A (1.00) | TNFRSF1A | |
| SCHEMBL5571669 | 0.81 | TNFRSF1A (1.00) | TNFRSF1A | |
| SCHEMBL5575698 | 0.79 | TNFRSF1A (0.71) | TNFRSF1ACYP1A1CYP1A2CYP1B1CYP3A4 | |
| SCHEMBL5576005 | 0.79 | TNFRSF1A (0.71) | TNFRSF1ACYP1A1CYP1A2CYP1B1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247714-B2 | Protection against oxidative stress and inflammation by a cytoprotective response element | ATHEROGENICS, INC. (US) | 2007-07-24 | — | — | US | disclosed |