Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 16/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14454081 | 0.83 | TNFRSF1A (1.00) | TNFRSF1A | |
| SCHEMBL5576289 | 0.83 | TNFRSF1A (1.00) | TNFRSF1A | |
| SCHEMBL5576279 | 0.79 | TNFRSF1A (0.69) | TNFRSF1AALDH1A1KDM4EMEN1TP53 | |
| SCHEMBL5573380 | 0.78 | TNFRSF1A (1.00) | TNFRSF1AMAPT | |
| SCHEMBL5573378 | 0.78 | TNFRSF1A (1.00) | TNFRSF1AMAPT | |
| SCHEMBL6110701 | 0.77 | TNFRSF1A (0.70) | TNFRSF1AABCG2 | |
| SCHEMBL6109483 | 0.76 | TNFRSF1A (0.65) | TNFRSF1AALDH1A1ABCG2MEN1TP53 | |
| SCHEMBL5571678 | 0.75 | TNFRSF1A (0.87) | TNFRSF1AALDH1A1KDM4EABCG2MEN1 | |
| SCHEMBL5575655 | 0.74 | TNFRSF1A (0.67) | TNFRSF1A | |
| SCHEMBL5575652 | 0.74 | TNFRSF1A (0.67) | TNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247714-B2 | Protection against oxidative stress and inflammation by a cytoprotective response element | ATHEROGENICS, INC. (US) | 2007-07-24 | — | — | US | disclosed |