Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.52 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | XIAP | P98170 | 1/20 | 0.48 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 6/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL22290100 | 0.97 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL3100805 | 0.97 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL1675510 | 0.97 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL10757101 | 0.96 | SLC7A5 (0.57) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL4405170 | 0.94 | SLC7A5 (0.54) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL2764420 | 0.94 | SLC7A5 (0.54) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL4612447 | 0.94 | SLC7A5 (0.54) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL10428633 | 0.94 | SLC7A5 (0.54) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL29198065 | 0.94 | SLC7A5 (0.54) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL3103204 | 0.94 | SLC7A5 (0.54) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070031439-A1 | Novel protein related to melanoma-inhibiting protein and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2007-02-08 | — | — | US | disclosed |
| US-20030224451-A1 | Novel protein related to melanoma-inhibiting protein and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2003-12-04 | — | — | US | disclosed |
| US-20020103360-A1 | Novel protein related to melanoma-inhibiting protein and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2002-08-01 | — | — | US | disclosed |