Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 5/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2084238 | 0.92 | CXCR4 (0.34) | CXCR4TMEM97SIGMAR1 | |
| SCHEMBL2084179 | 0.84 | TMEM97 (0.32) | TMEM97SIGMAR1 | |
| SCHEMBL5576613 | 0.82 | CXCR4 (0.33) | CXCR4TMEM97SIGMAR1CHRM2 | |
| SCHEMBL2084996 | 0.81 | CXCR4 (0.39) | CXCR4MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2084718 | 0.80 | CXCR4 (0.41) | CXCR4TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL2085372 | 0.80 | CXCR4 (0.41) | CXCR4KDM4EALDH1A1CHRM2 | |
| SCHEMBL5576002 | 0.78 | CXCR4 (0.37) | CXCR4TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL2084931 | 0.77 | CXCR4 (0.52) | CXCR4CHRM2 | |
| SCHEMBL2083918 | 0.76 | CXCR4 (0.35) | CXCR4CHRM2 | |
| SCHEMBL2085688 | 0.76 | CXCR4 (0.35) | CXCR4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291631-B2 | CXCR4 chemokine receptor binding compounds | GENZYME CORPORATION (US) | 2007-11-06 | — | — | US | claimed |