Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 14/20 | 0.44 |
| ▸ | AKT1 | P31749 | 11/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 4/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1791225 | 0.88 | RPS6KB1 (0.49) | RPS6KB1AKT1 | |
| SCHEMBL1791694 | 0.75 | RPS6KB1 (0.65) | RPS6KB1AKT1 | |
| SCHEMBL1792924 | 0.74 | RPS6KB1 (0.61) | RPS6KB1AKT1 | |
| SCHEMBL1794254 | 0.72 | RPS6KB1 (0.43) | RPS6KB1AKT1 | |
| SCHEMBL1794366 | 0.72 | RPS6KB1 (0.55) | RPS6KB1AKT1HTR1A | |
| SCHEMBL1788529 | 0.70 | RPS6KB1 (0.69) | RPS6KB1AKT1 | |
| SCHEMBL1792541 | 0.69 | RPS6KB1 (0.68) | RPS6KB1AKT1 | |
| SCHEMBL1792988 | 0.69 | RPS6KB1 (0.46) | RPS6KB1AKT1 | |
| SCHEMBL1788484 | 0.68 | RPS6KB1 (0.68) | RPS6KB1AKT1 | |
| SCHEMBL1789602 | 0.67 | RPS6KB1 (0.67) | RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750727-A2 | KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005117909-A2 | KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |