Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 18/20 | 0.44 |
| ▸ | AKT1 | P31749 | 9/20 | 0.44 |
| ▸ | AKT2 | P31751 | 3/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5577231 | 0.84 | RPS6KB1 (0.43) | RPS6KB1AKT1AKT2RPS6KA3 | |
| Trifluoroacetic Acid SCHEMBL4931514 | 0.83 | RPS6KB1 (0.57) | RPS6KB1AKT1AKT2RPS6KA3 | |
| Trifluoroacetic Acid SCHEMBL4923234 | 0.83 | RPS6KB1 (0.58) | RPS6KB1AKT1AKT2RPS6KA3 | |
| Trifluoroacetic Acid SCHEMBL4932460 | 0.82 | RPS6KB1 (0.44) | RPS6KB1AKT1AKT2RPS6KA3 | |
| SCHEMBL4923245 | 0.80 | RPS6KB1 (0.48) | RPS6KB1AKT1AKT2RPS6KA3 | |
| Trifluoroacetic Acid SCHEMBL4931218 | 0.77 | RPS6KB1 (0.63) | RPS6KB1AKT1AKT2RPS6KA3 | |
| Trifluoroacetic Acid SCHEMBL4925257 | 0.76 | RPS6KB1 (0.46) | RPS6KB1AKT1AKT2RPS6KA3 | |
| Trifluoroacetic Acid SCHEMBL4926398 | 0.76 | RPS6KB1 (0.48) | RPS6KB1AKT1AKT2RPS6KA3 | |
| SCHEMBL4931519 | 0.76 | RPS6KB1 (0.48) | RPS6KB1AKT1AKT2RPS6KA3 | |
| Trifluoroacetic Acid SCHEMBL4930137 | 0.75 | RPS6KB1 (0.52) | RPS6KB1AKT1AKT2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750727-A2 | KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005117909-A2 | KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |