Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.46 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.46 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.46 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.46 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5578518 | 0.79 | DYRK1A (0.51) | DYRK1ACLK4CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL577887 | 0.77 | CA12 (0.46) | DYRK1ACLK4KDM4EKMT2ARAB9A | |
| SCHEMBL196765 | 0.76 | CYP3A4 (0.73) | DYRK1ACLK4CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL29489425 | 0.76 | CYP3A4 (0.73) | DYRK1ACLK4CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL5578517 | 0.76 | DYRK1A (0.56) | DYRK1ACLK4CYP1A1CYP1A2CYP2E1 | |
| Hydrogen Sulfide SCHEMBL28640169 | 0.74 | CYP3A4 (0.70) | DYRK1ACLK4CYP1A1CYP1A2CYP2E1 | |
| Ammonia Solution, Strong SCHEMBL27960505 | 0.74 | CYP3A4 (0.70) | DYRK1ACLK4CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL29628977 | 0.74 | CYP3A4 (0.77) | DYRK1ACLK4CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL7682548 | 0.74 | DYRK1A (0.50) | DYRK1ACLK4CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL1180343 | 0.72 | ABL1 (0.69) | DYRK1ACLK4CYP1A1CYP1A2CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021330-A1 | Aza-peptide macrocyclic hepatitis c serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2007-01-25 | — | — | US | claimed |
| US-7125845-B2 | Aza-peptide macrocyclic hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2006-10-24 | — | — | US | claimed |
| US-20050065073-A1 | Aza-peptide macrocyclic hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. | 2005-03-24 | — | — | US | claimed |
| WO-2005010029-A1 | AZA-PEPTIDE MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2005-02-03 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021330-A1 | Aza-peptide macrocyclic hepatitis c serine protease inhibitors | VIP, CTSC, DPP4 | DYRK1A 4756/4885CLK4 4491/4885CYP1A1 1388/4885 |
| US-20050065073-A1 | Aza-peptide macrocyclic hepatitis C serine protease inhibitors | VIP, CTSC, PRSS1 | DYRK1A 4764/4885CLK4 4536/4885CYP1A1 1343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.