Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CCKBR | P32239 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5082222 | 1.00 | IDO1 (0.52) | IDO1HDAC6HDAC8HDAC1HDAC4 | |
| SCHEMBL5078957 | 1.00 | IDO1 (0.52) | IDO1HDAC6HDAC8HDAC1HDAC4 | |
| SCHEMBL5082100 | 0.89 | IDO1 (0.55) | IDO1HDAC6HDAC8HDAC1HDAC4 | |
| SCHEMBL5079028 | 0.89 | IDO1 (0.55) | IDO1HDAC6HDAC8HDAC1HDAC4 | |
| Benzodiazepinedione SCHEMBL10968598 | 0.81 | IDO1 (0.65) | IDO1GSK3BCCKBRMEN1KMT2A | |
| Benzodiazepinedione SCHEMBL29799531 | 0.81 | IDO1 (0.65) | IDO1GSK3BCCKBRMEN1KMT2A | |
| Benzodiazepinedione SCHEMBL10832629 | 0.81 | IDO1 (0.65) | IDO1GSK3BCCKBRMEN1KMT2A | |
| SCHEMBL5579378 | 0.76 | HDAC3 (0.53) | IDO1HDAC6HDAC8HDAC1GSK3B | |
| SCHEMBL5579382 | 0.76 | HDAC3 (0.53) | IDO1HDAC6HDAC8HDAC1GSK3B | |
| SCHEMBL5081684 | 0.74 | GAA (0.54) | HDAC6HDAC8HDAC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070155730-A1 | Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase | METHYLGENE, INC. (CA) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155730-A1 | Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase | HDAC5, HDAC4, HDAC3 | IDO1 1753/4885HDAC6 24/4885HDAC8 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.