Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.37 |
| ▸ | CTSD | P07339 | 3/20 | 0.37 |
| ▸ | CTSB | P07858 | 12/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5579837 | 1.00 | BACE1 (0.37) | BACE1CTSDCTSBPKMMAPK1 | |
| SCHEMBL3349464 | 0.82 | BACE1 (0.52) | BACE1CTSDCTSB | |
| SCHEMBL13308163 | 0.82 | BACE1 (0.52) | BACE1CTSDCTSB | |
| SCHEMBL3349472 | 0.82 | BACE1 (0.52) | BACE1CTSDCTSB | |
| SCHEMBL5130433 | 0.79 | BACE1 (0.41) | BACE1CTSDCTSB | |
| SCHEMBL5130424 | 0.79 | BACE1 (0.41) | BACE1CTSDCTSB | |
| SCHEMBL5125521 | 0.78 | BACE1 (0.39) | BACE1CTSDCTSB | |
| SCHEMBL5125526 | 0.78 | BACE1 (0.39) | BACE1CTSDCTSB | |
| SCHEMBL5125163 | 0.78 | MEN1 (0.45) | PKMMAPK1SMN1; SMN2MAPT | |
| SCHEMBL5125172 | 0.78 | MEN1 (0.45) | PKMMAPK1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294642-B2 | 1,3-Diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-11-13 | — | — | US | claimed |