Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 5/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5580055 | 0.94 | HPGD (0.43) | HPGDGABRA1GABRB2ALDH1A1KMT2A | |
| SCHEMBL5127261 | 0.88 | BACE1 (0.47) | HPGDGABRA1GABRB2KMT2AMEN1 | |
| SCHEMBL5127255 | 0.88 | BACE1 (0.47) | HPGDGABRA1GABRB2KMT2AMEN1 | |
| SCHEMBL6171452 | 0.87 | BACE1 (0.42) | ALDH1A1BACE1BACE2CTSD | |
| SCHEMBL5579642 | 0.84 | BACE1 (0.54) | BACE1BACE2CTSD | |
| SCHEMBL5118766 | 0.82 | BACE1 (0.46) | HPGDGABRA1GABRB2ALDH1A1KMT2A | |
| SCHEMBL5118756 | 0.82 | BACE1 (0.46) | HPGDGABRA1GABRB2ALDH1A1KMT2A | |
| SCHEMBL5129917 | 0.82 | BACE1 (0.42) | USP2SLC6A2SLC6A4SLC6A3BACE1 | |
| SCHEMBL5129920 | 0.82 | BACE1 (0.42) | USP2SLC6A2SLC6A4SLC6A3BACE1 | |
| SCHEMBL6697280 | 0.81 | BACE1 (0.54) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294642-B2 | 1,3-Diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-11-13 | — | — | US | claimed |