Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 12/20 | 0.39 |
| ▸ | CTSD | P07339 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 9/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5580030 | 1.00 | MAPT (0.41) | MAPTALDH1A1POLBKDM4EGAA | |
| SCHEMBL3351055 | 0.82 | BACE1 (0.57) | MAPTALDH1A1POLBKDM4EGAA | |
| SCHEMBL3351050 | 0.82 | BACE1 (0.57) | MAPTALDH1A1POLBKDM4EGAA | |
| SCHEMBL13308149 | 0.82 | BACE1 (0.57) | MAPTALDH1A1POLBKDM4EGAA | |
| SCHEMBL5124829 | 0.82 | BACE1 (0.42) | BACE1CTSDCTSB | |
| SCHEMBL5127690 | 0.81 | BACE1 (0.43) | BACE1CTSDCTSB | |
| SCHEMBL5127687 | 0.81 | BACE1 (0.43) | BACE1CTSDCTSB | |
| SCHEMBL5130961 | 0.79 | BACE1 (0.39) | BACE1CTSDNPC1RAB9ACTSB | |
| SCHEMBL5130953 | 0.79 | BACE1 (0.39) | BACE1CTSDNPC1RAB9ACTSB | |
| SCHEMBL5120482 | 0.79 | BACE1 (0.38) | BACE1CTSDCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294642-B2 | 1,3-Diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-11-13 | — | — | US | claimed |
| US-7294642-B2 | 1,3-Diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-11-13 | — | — | US | disclosed |