Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | ACP3 | P15309 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5580154 | 1.00 | DRD4 (0.49) | DRD4ACP3PLK1NR1H4MEN1 | |
| SCHEMBL5580180 | 0.90 | DEGS1 (0.49) | DRD4PLK1NR1H4MEN1KMT2A | |
| SCHEMBL5580183 | 0.90 | DEGS1 (0.49) | DRD4PLK1NR1H4MEN1KMT2A | |
| SCHEMBL5580159 | 0.85 | CCR3 (0.49) | MEN1KMT2AMAPT | |
| SCHEMBL5580161 | 0.85 | CCR3 (0.49) | MEN1KMT2AMAPT | |
| SCHEMBL5580151 | 0.76 | CCR3 (0.49) | NR1H4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL5580149 | 0.76 | CCR3 (0.49) | NR1H4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL5580405 | 0.75 | APEX1 (0.44) | KMT2AALDH1A1MAPT | |
| SCHEMBL5580402 | 0.75 | APEX1 (0.44) | KMT2AALDH1A1MAPT | |
| SCHEMBL485144 | 0.73 | CXCR2 (0.56) | MEN1KMT2AALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420424-B1 | ADMINISTERING PHENYLALANINE AMIDE DERIVATIVES (SUCH AS S-ETHYL-2-AMINO-3-(4-CHLOROPHENYL)PROPIONATE HYDROCHLORIDE) TO TREAT ALLERGIC DISORDERS, INCLUDING ASTHMA, RHINITIS, DERMATITUS, AND PRURITIS | SMITHKLINE BEECHAM CORPORATION | 2002-07-16 | — | — | US | claimed |
| US-20070249915-A1 | Inhibitors | SHISEIDO COMPANY, LTD. (JP) | 2007-10-25 | — | — | US | disclosed |