SCHEMBL558022

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL10222231	0.88	APP (0.47)	APPTLR4XDHNLRP3KDM4E
	SCHEMBL10272010	0.86	APP (0.49)	APPTLR4XDHNLRP3KDM4E
	SCHEMBL557873	0.83	APP (0.53)	APPTLR4XDHNLRP3KDM4E
	SCHEMBL559493	0.81	KDM4E (0.47)	TLR4XDHNLRP3KDM4EMAPT
	SCHEMBL6791597	0.74	APP (0.59)	APPTLR4XDHNLRP3KDM4E
	SCHEMBL558021	0.72	PIK3CG (0.56)	APPTLR4XDHNLRP3KDM4E
	Coixol SCHEMBL29999166	0.72	APP (0.54)	APPTLR4XDHNLRP3KDM4E
	SCHEMBL558568	0.71	MAPT (0.51)	XDHKDM4EPOLBMAPTALDH1A1
	SCHEMBL2421219	0.69	APP (0.54)	APPTLR4XDHNLRP3KDM4E
	SCHEMBL12778280	0.69	APP (0.54)	APPTLR4XDHNLRP3KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.