SCHEMBL5581020

SCHEMBL5581020

COc1ccc(C(=O)O)c(Oc2nc(Oc3cccc(-c4cccc(C(=N)N)c4)c3)c(F)c(C)c2F)c1

nearest known ligand 0.81

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PLG P00747 2/20 0.81
PLAU P00749 2/20 0.81
PLAT P00750 1/20 0.81
F10 P00742 14/20 0.72
F7 P08709 2/20 0.70
F3 P13726 2/20 0.70
F2 P00734 5/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5581396 0.89 PLG (0.78) PLGPLAUPLATF10F7
SCHEMBL5580850 0.89 F7 (0.89) PLGPLAUPLATF10F7
SCHEMBL5580879 0.86 F10 (0.89) PLGPLAUPLATF10F7
SCHEMBL5581753 0.85 PLAU (0.83) PLGPLAUPLAT
SCHEMBL5581324 0.85 F3 (0.72) PLGPLAUPLATF10F7
SCHEMBL5581733 0.82 PLG (0.66) PLGPLAUPLATF10F7
SCHEMBL6578747 0.81 F10 (1.00) F10F2
SCHEMBL6576440 0.80 F10 (1.00) F10F7F3F2
SCHEMBL5581381 0.80 F10 (0.77) PLGPLAUPLATF10F2
SCHEMBL5581205 0.80 F10 (0.87) PLGPLAUPLATF10F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070148164-A1 Neonatal Fc receptor (FcRn)-binding polypeptide variants, dimeric Fc binding proteins and methods related thereto BIOGEN IDEC MA INC. (US) 2007-06-28 US disclosed