Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.36 |
| ▸ | IDH1 | O75874 | 3/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.34 |
| ▸ | JUN | P05412 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13696558 | 0.82 | HRH4 (0.38) | HRH4CXCR4CCNKCDK12MAPK8 | |
| SCHEMBL2010696 | 0.82 | HRH4 (0.38) | HRH4CXCR4CCNKCDK12MAPK8 | |
| SCHEMBL4114629 | 0.75 | HRH4 (0.47) | HRH4CXCR4MAPK8MAPK9CCNB2 | |
| SCHEMBL4113776 | 0.73 | HRH4 (0.48) | HRH4CXCR4MAPK8MAPK9CCNB2 | |
| SCHEMBL2012554 | 0.71 | CXCR4 (0.45) | HRH4CXCR4CCNKCDK12HSD11B1 | |
| SCHEMBL13696542 | 0.71 | CXCR4 (0.45) | HRH4CXCR4CCNKCDK12HSD11B1 | |
| SCHEMBL14391832 | 0.71 | CXCR4 (0.45) | HRH4CXCR4CCNKCDK12HSD11B1 | |
| SCHEMBL1090334 | 0.71 | HRH4 (0.57) | HRH4CXCR4MAPK8IDH1CDK2 | |
| SCHEMBL13696544 | 0.71 | CXCR4 (0.45) | HRH4CXCR4CCNKCDK12HSD11B1 | |
| SCHEMBL2011381 | 0.71 | CXCR4 (0.45) | HRH4CXCR4CCNKCDK12HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203089-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPHTHALMIC DISEASE | ALLERGAN, INC. | 2007-08-30 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203089-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPHTHALMIC DISEASE | CXCL12, CXCR4, PDE6C | HRH4 2600/4885CXCR4 2/4885CCNK 2786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.