SCHEMBL5581880

SCHEMBL5581880

COc1cc(Oc2nc(Oc3cc(C)sc3C(=O)O)c(F)cc2F)cc(-c2cccc(CN)c2)c1

nearest known ligand 0.65

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PLAU P00749 20/20 0.65
PLG P00747 14/20 0.65
PLAT P00750 7/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5581380 0.93 PLAU (0.66) PLAUPLGPLAT
SCHEMBL5580991 0.91 PLAU (0.66) PLAUPLGPLAT
SCHEMBL5580674 0.87 PLAU (0.66) PLAUPLGPLAT
SCHEMBL5580884 0.84 PLAU (0.88) PLAUPLGPLAT
SCHEMBL5580978 0.82 PLAU (0.75) PLAUPLGPLAT
SCHEMBL5580949 0.81 PLAU (0.66) PLAUPLGPLAT
Hydrochloric Acid SCHEMBL5581916 0.80 PLAU (0.82) PLAUPLGPLAT
Hydrochloric Acid SCHEMBL5581913 0.80 PLAU (0.82) PLAUPLGPLAT
SCHEMBL5581934 0.80 PLAU (0.77) PLAUPLGPLAT
SCHEMBL5581534 0.80 PLAU (0.84) PLAUPLGPLAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070148164-A1 Neonatal Fc receptor (FcRn)-binding polypeptide variants, dimeric Fc binding proteins and methods related thereto BIOGEN IDEC MA INC. (US) 2007-06-28 US disclosed