Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.32 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23651 | 0.96 | — | — | |
| SCHEMBL28274580 | 0.96 | TSHR (0.46) | TSHRLMNATHRBDNM1ALDH1A1 | |
| SCHEMBL28214924 | 0.92 | TSHR (0.43) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Magnesium SCHEMBL30615773 | 0.92 | TSHR (0.43) | TSHRLMNATHRBDNM1ALDH1A1 | |
| SCHEMBL27780843 | 0.92 | TSHR (0.43) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3861701 | 0.92 | TSHR (0.43) | TSHRLMNATHRBDNM1ALDH1A1 | |
| SCHEMBL10957741 | 0.92 | TSHR (0.43) | TSHRLMNATHRBDNM1ALDH1A1 | |
| SCHEMBL28990436 | 0.92 | TSHR (0.43) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Hexane SCHEMBL1710905 | 0.92 | TSHR (0.50) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Methane SCHEMBL28167680 | 0.92 | TSHR (0.43) | TSHRLMNATHRBDNM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7273948-B2 | Process of preparing esters and ethers of probucol and derivatives thereof | ATHEROGENICS, INC. (US) | 2007-09-25 | — | — | US | claimed |
| CN-104023996-B | For the method for the polydiene and polydiene copolymer that prepare the cold flow with reduction | 株式会社普利司通 | 2017-10-24 | — | — | CN | disclosed |
| CN-104125967-B | For preparing the bulk polymerization of polydiene | 株式会社普利司通 | 2016-11-09 | — | — | CN | disclosed |
| CN-104220466-B | For the method preparing polydiene | 株式会社普利司通 | 2016-09-21 | — | — | CN | disclosed |
| CN-103459402-B | Lanthanide complexes catalyst and use its polymerization | 株式会社普利司通 | 2016-09-07 | — | — | CN | disclosed |
| CN-103476780-B | Lanthanide complex catalysts and polymerization methods using the same | 株式会社普利司通 | 2016-08-17 | — | — | CN | disclosed |
| CN-103857704-B | By the lactone containing shielded amino or the functionalized polymkeric substance of thiolactone | BRIDGESTONE CO.,LTD. (JP) | 2016-02-17 | — | — | CN | disclosed |
| CN-104640843-A | 1-(cycloalkyl-carbonyl)proline derivative | DAINIPPON SUMITOMO PHARMA CO | 2015-05-20 | — | — | CN | disclosed |
| CN-104220466-A | Process for producing polydienes | BRIDGESTSONE CORP | 2014-12-17 | — | — | CN | disclosed |
| CN-104125967-A | Bulk polymerization process for producing polydienes | BRIDGESTONE CORP | 2014-10-29 | — | — | CN | disclosed |
| CN-103459402-A | Lanthanide complex catalyst and polymerization method employing same | BRIDGESTONE CORP | 2013-12-18 | — | — | CN | disclosed |
| CN-103443108-A | Metal complex catalyst and polymerization method using same | BRIDGESTONE CORP | 2013-12-11 | — | — | CN | disclosed |
| CN-101516916-B | Preparation of telechelic compounds by metathesis depolymerization | DOW GLOBAL TECHNOLOGIES INC | 2011-09-28 | — | — | CN | disclosed |
| CN-101516916-A | Preparation of telechelic compounds by metathesis depolymerization | DOW GLOBAL TECHNOLOGIES INC (US) | 2009-08-26 | — | — | CN | disclosed |
| CN-1255443-C | Olefin polymerization catalyst, process for producing olefin polymer, and olefin polymer | IDEMITSU KOSAN CO (JP) | 2006-05-10 | — | — | CN | disclosed |
| CN-1161386-C | Olefin polymerization catalyst, process for producing olefin polymer, and olefin polymer | 出光石油化学株式会社 | 2004-08-11 | — | — | CN | disclosed |
| CN-1150222-C | Process for preparing polyolefin polymerization catalysts | LG��ѧ��ʽ���� | 2004-05-19 | — | — | CN | disclosed |
| CN-1073575-C | Ethylen-alpha alkene copolymer and products formed with same | SUMITOMO CHEMICAL CO (JP) | 2001-10-24 | — | — | CN | disclosed |
| CN-1315968-A | Process for preparing olefin polymerization catalyst | LG CHEMICAL LTD (KR) | 2001-10-03 | — | — | CN | disclosed |
| CN-1087648-A | Ethylene-alpha-olefin copolymer and use this multipolymer and the moulding product of moulding | SUMITOMO CHEMICAL CO (JP) | 1994-06-08 | — | — | CN | disclosed |