Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.59 |
| ▸ | CLK2 | P49760 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5583263 | 1.00 | KDM4E (0.66) | KDM4EMAPTHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL14366543 | 1.00 | KDM4E (0.66) | KDM4EMAPTHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL5583200 | 0.98 | KDM4E (0.69) | KDM4EMAPTHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL5583198 | 0.98 | KDM4E (0.69) | KDM4EMAPTHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL14366545 | 0.98 | KDM4E (0.69) | KDM4EMAPTHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL5239415 | 0.80 | KDM4E (1.00) | KDM4EMAPTHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL5583148 | 0.79 | KDM4E (0.98) | KDM4EMAPTHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL4255908 | 0.77 | KDM4E (0.71) | KDM4EMAPTHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL1658107 | 0.77 | KDM4E (0.71) | KDM4EMAPTHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL5583246 | 0.76 | KDM4E (0.56) | KDM4EMAPTHSD17B10SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254877-A1 | Indole Derivative and Use for Treatment of Cancer | TAKADA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254877-A1 | Indole Derivative and Use for Treatment of Cancer | IGF1R, KDR, ERBB2 | KDM4E 1419/4885MAPT 4824/4885HSD17B10 2043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.