Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 1.00 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.79 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.79 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.79 |
| ▸ | BTK | Q06187 | 2/20 | 0.74 |
| ▸ | GAK | O14976 | 1/20 | 0.72 |
| ▸ | FES | P07332 | 1/20 | 0.72 |
| ▸ | FER | P16591 | 1/20 | 0.72 |
| ▸ | TEC | P42680 | 1/20 | 0.72 |
| ▸ | CLK1 | P49759 | 1/20 | 0.72 |
| ▸ | JAK3 | P52333 | 1/20 | 0.72 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.72 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.72 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717532 | 0.91 | EGFR (1.00) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL12519518 | 0.89 | EGFR (1.00) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL29722500 | 0.89 | EGFR (1.00) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL28679831 | 0.89 | EGFR (0.80) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL17197360 | 0.89 | EGFR (1.00) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL4560138 | 0.89 | EGFR (1.00) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL5585381 | 0.88 | EGFR (1.00) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL9923758 | 0.88 | EGFR (0.82) | EGFRERBB3ERBB2ERBB4BTK | |
| SCHEMBL5585054 | 0.88 | EGFR (1.00) | EGFR | |
| SCHEMBL9893739 | 0.87 | EGFR (1.00) | EGFRERBB3ERBB2ERBB4BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10081606-B2 | Heteroaryl compounds and uses thereof | CELGENE CAR LLC (BM) | 2018-09-25 | — | — | US | disclosed |
| US-20180072687-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2018-03-15 | — | — | US | disclosed |
| US-20180072687-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2018-03-15 | — | — | US | disclosed |
| US-9765038-B2 | Heteroaryl compounds and uses thereof | CELGENE CAR LLC (BM) | 2017-09-19 | — | — | US | disclosed |
| US-9765038-B2 | Heteroaryl compounds and uses thereof | CELGENE CAR LLC (BM) | 2017-09-19 | — | — | US | disclosed |
| EP-2635285-B1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RES INC (US) | 2017-05-03 | — | — | EP | disclosed |
| EP-2635285-B1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RES INC (US) | 2017-05-03 | — | — | EP | disclosed |
| US-20160130236-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2016-05-12 | — | — | US | disclosed |
| US-20160130236-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2016-05-12 | — | — | US | disclosed |
| US-9238629-B2 | Heteroaryl compounds and uses thereof | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-01-19 | — | — | US | disclosed |
| US-9238629-B2 | Heteroaryl compounds and uses thereof | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-01-19 | — | — | US | disclosed |
| US-20120149722-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120149722-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
| WO-2012061303-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072687-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | EGFR 1981/4885ERBB3 294/4885ERBB2 918/4885 |
| US-20160130236-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | EGFR 1981/4885ERBB3 294/4885ERBB2 918/4885 |
| US-20120149722-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | EGFR 1981/4885ERBB3 294/4885ERBB2 918/4885 |
| US-10081606-B2 | Heteroaryl compounds and uses thereof | ABCG2, CYP3A43, CYP3A5 | EGFR 1981/4885ERBB3 294/4885ERBB2 918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.