Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 13/20 | 0.45 |
| ▸ | BRAF | P15056 | 11/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4869600 | 0.86 | SYK (0.57) | SYKRAF1BRAFDDR2LCK | |
| SCHEMBL4879790 | 0.84 | SYK (0.59) | SYKRAF1BRAFDDR2LCK | |
| SCHEMBL4879453 | 0.82 | BTK (0.62) | SYKRAF1BRAFDDR2ABL1 | |
| SCHEMBL4879441 | 0.80 | BRAF (0.57) | SYKRAF1BRAFDDR2LCK | |
| SCHEMBL4879496 | 0.79 | BTK (0.59) | SYKRAF1BRAFDDR2ABL1 | |
| SCHEMBL4879885 | 0.79 | LCK (0.66) | SYKRAF1BRAFDDR2LCK | |
| SCHEMBL4870778 | 0.79 | SYK (0.61) | SYKRAF1BRAFDDR2LCK | |
| SCHEMBL4880464 | 0.79 | LCK (0.65) | SYKRAF1BRAFDDR2ABL1 | |
| SCHEMBL4869644 | 0.79 | SYK (0.58) | SYKRAF1BRAFDDR2LCK | |
| SCHEMBL4879771 | 0.79 | SYK (0.63) | SYKRAF1BRAFDDR2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765820-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-03-28 | — | — | EP | claimed |
| WO-2006002367-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-01-05 | — | — | WO | claimed |